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NUCLEOTIDE OLIGOMERIZATION DOMAIN 2 PROTEIN
Descriptors Found:
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DeCS
Descriptor
English
:
Nod2 Signaling Adaptor Protein
Descriptor
Spanish
:
Proteína Adaptadora de Señalización NOD2
Descriptor
Portuguese
:
Proteína Adaptadora de Sinalização NOD2
Synonyms
English
:
CARD15 Protein
Caspase Recruitment Domain Protein 15
Nucleotide Oligomerization Domain 2 Protein
Tree Number:
D12.644.360.024.131.500
D12.644.360.024.313.500
D12.644.360.075.358.500
D12.644.360.539.500.500
D12.776.157.057.006.500
D12.776.157.057.078.500
D12.776.476.024.139.500
D12.776.476.024.391.500
D12.776.476.075.358.500
Definition
English
:
A NOD signaling adaptor protein that contains two C-terminal leucine-rich domains which recognize bacterial
PEPTIDOGLYCAN
. It signals via an N-terminal capase recruitment domain that interacts with other
CARD SIGNALING ADAPTOR PROTEINS
such as RIP SERINE-THEONINE KINASES. The protein plays a role in the host defense response by signaling the activation of
CASPASES
and the
MAP KINASE SIGNALING SYSTEM
.
Mutations
of the gene encoding the nucleotide oligomerization domain 2 protein have been associated with increased susceptibility to
CROHN DISEASE.
History Note
English
:
2007
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
52307
Unique Identifier:
D053473
Occurrence in VHL
:
Similar:
DeCS